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Cardiovascular epidemiology

A great challenge within CVD epidemiology is the marked and rapid changes over time in prevalence, incidence, mortality and clinical presentation.

Specific aims for our studies include:

  • Description and analysis of changes in risk factors and CVD prevalence and incidence for men and women in Sweden and in Gothenburg.
  • Effects of risk factors such as obesity and psychosocial factors for the development of various manifestations of CVD in Gothenburg populations of men and women.
  • Trends in incidence, mortality and survival in CVD
  • The study of the influence of societal and individual factors on the development of CVD

We have a well developed ongoing international network:
PURE = Prospective Urban Rural Epidemiologic study is a prospective cohort study coordinated from McMaster’s University, Hamilton, Canada, (PI professor Salim Yusuf) with ongoing data collection in 17 countries, chiefly low- and middle income countries in Asia, Africa and Latin America. Ours is the only European data collection centre (Gothenburg and Skaraborg). The PURE study aims to determine individual and societal determinants for chronic diseases in a total of 153 996 men and women worldwide.

INTERHEART is a global case-control study of 15,000 patients with acute myocardial infarction and an equal number of controls.

Swedish IMPACT model in collaboration with professor Simon Capewell, University of Liverpool aims to quantify the relative contributions of changes in risk factors and medical treatment for the reduction in CHD mortality.

Work area 1: Psychosocial factors and susceptibility to cardiovascular diseases

Selected publications:

Rosengren A, Dotevall A, Eriksson H, Wilhelmsen L. Optimal risk factors in the population: prognosis, prevalence, and secular trends; data from Goteborg population studies. Eur Heart J 2001;22:136-44.

Rosengren A, Spetz CL, Koster M, Hammar N, Alfredsson L, Rosen M. Sex differences in survival after myocardial infarction in Sweden; data from the Swedish National Acute Myocardial Infarction Register. Eur Heart J 2001;22:314-22.

Schaufelberger M, Rosengren A. Heart failure in different occupational classes in Sweden. Eur Heart J 2007;28:212-8.

Anand SS, Islam S, Rosengren A, Franzosi MG, Steyn K, Yusufali AH, Keltai M, Diaz R, Rangarajan S, Yusuf S. Risk factors for myocardial infarction in women and men: insights from the INTERHEART study. Eur Heart J 2008;29:932-940.

Rosengren A, Fredén M, Hansson PO, Wilhelmsen L, Wedel H, Eriksson H. Psychosocial factors and venous thromboembolism: a long-term follow-up study of Swedish men. J Thromb Haemost 2008;6:558-64.

Jerlock M, Kjellgren KI, Gaston-Johansson F, Lissner L, Manhem K, Rosengren A, Welin C. Psychosocial profile in men and women with unexplained chest pain. J Intern Med 2008;264:265-74.

Shafazand M, Schaufelberger M, Lappas G, Swedberg K, Rosengren A. Survival trends in men and women with heart failure of ischaemic and non-ischaemic origin: data for the period 1987-2003 from the Swedish Hospital Discharge Registry. Eur Heart J 2009;30:671-8.

Björck L, Rosengren A, Bennett K, Lappas G, Capewell S. Modelling the decreasing coronary heart disease mortality in Sweden between 1986 and 2002. Eur Heart J 2009;30:1046-56.

Rosengren A, Subramanian SV, Islam S, Chow CK, Avezum A, Kazmi K, Sliwa K, Zubaid M, Rangarajan S, Yusuf S. Education and risk for acute myocardial infarction in 52 high, middle and low-income countries: INTERHEART case-control study. Heart 2009;95:2014-22.

Rosengren A, Hauptman PJ, Lappas G, Olsson L, Wilhelmsen L, Swedberg K. Big men and atrial fibrillation: effects of body size and weight gain on risk of atrial fibrillation in men. Eur Heart J 2009;30:1113-20.

Rosengren A, Eriksson H, Hansson PO, Svärdsudd K, Wilhelmsen L, Johansson S, Welin C, Welin L. Obesity and trends in cardiovascular risk factors over 40 years in Swedish men aged 50. J Intern Med 2009;266:268-76.

Björck L, Wallentin L, Stenestrand U, Lappas G, Rosengren A. Medication in relation to ST-segment elevation myocardial infarction in patients with a first MI: (RIKS-HIA). Arch Intern Med 2010;170:1375-81.

Fagring AJ, Lappas G, Kjellgren KI, Welin C, Manhem K, Rosengren A. Twenty-year trends in incidence and 1-year mortality in Swedish patients hospitalised with non-AMI chest pain. Data from 1987-2006 from the Swedish hospital and death registries. Heart 2010;96:1043-9.

Shafazand M, Rosengren A, Lappas L, Swedberg K, Schaufelberger M. Decreasing trends in the incidence of heart failure after acute myocardial infarction from 1993-2004. A Study of 175,216 Patients With a First AMI in Sweden. Eur J Heart Failure 2011;13:135-41.

Stewart S, Ekman I, Ekman T, Odén A, Rosengren A. Population impact of heart failure and the most common forms of cancer: A study of 1,162,309 hospital cases in Sweden (1988-2004). Circulation: Cardiovascular Quality and Outcomes 2010;3:573-80.

Dudas K, Lappas G, Stewart S, Rosengren A. Trends in out-of-hospital deaths from coronary heart disease in Sweden (1991 to 2006). Circulation 2011;123:46-52.

Lind M, Bounias I, Olsson M, Gudbjörnsdottir S, Svensson AM, Rosengren A. Glycaemic control and incidence of heart failure in 20,985 patients with type 1 diabetes: an observational study. Lancet 2011;378:140-6.

Yusuf S, Islam S, Chow CK, Rangarajan S, Dagenais G, Diaz R, Gupta R, Kelishadi R, Iqbal R, Avezum A, Kruger A, Kutty R, Lanas F, Lisheng L, Wei L, Lopez-Jaramillo P, Oguz A, Rahman O, Swidan H, Yusoff K, Zatonski W, Rosengren A, Teo KK; Prospective Urban Rural Epidemiology (PURE) Study Investigators. Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey. Lancet 2011;378:1231-43

Novak M, Björck L, Giang KW, Heden-Ståhl C, Wilhelmsen L, Rosengren A. Perceived stress and incidence of Type 2 diabetes: a 35-year follow-up study of middle-aged Swedish men. Diabet Med. 2013 Jan;30(1):e8-e16.

Giang KW, Björck L, Novak M, Lappas G, Wilhelmsen L, Torén K, Rosengren A. Stroke and coronary heart disease: predictive power of standard risk factors into old age long-term cumulative risk study among men in Gothenburg, Sweden. Eur Heart J. 2013 Jan 9. [Epub ahead of print]

Page Manager: Katarina Englund|Last update: 2/12/2013

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